Emetine hydrochloride and chloroquine in the treatment of children with amoebic liver abscess.
نویسندگان
چکیده
Although amoebic liver abscess is infrequent in children, the outcome is much less favourable than it is in adults. When treated with combined emetine hydrochloride, chloroquine, and aspiration, the prognosis is excellent in adults (Wilmot, 1962), this regime being more successful than treatment with a single drug (Wilmot, Powell, and Adams, 1959; Wilmot, Powell, MacLeod, and Elsdon-Dew, 1964). In children our current therapy is similar to that employed successfully in adults, but our mortality has been over 50% (Scragg, 1960). In this short paper we compare the results of treatment in two groups of children with amoebic liver abscess, the one group treated with emetine hydrochloride and the other with chloroquine. This trial was designed to determine whether the high mortality in children might be due to the toxic effect of emetine, particularly on the myocardium.
منابع مشابه
Children with Amoebic Liver Abscess
A combination of emetine hydrochloride with chloroquine yields better results than either drug alone in the treatment of amoebic liver abscess in adults (Wilmot, Powell, and Adams, 1959). A similar combination of dehydroemetine with chloroquine is equally satisfactory (Wilmot, Powell, MacLeod, and Elsdon-Dew, 1964; Powell, Wilmot, MacLeod, and Elsdon-Dew, 1967). Dehydroemetine is claimed to be ...
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say very little on the value of hypodermic injections of emetine hydrochloride introduced by me last year, as the rapid specific curative action of this treatment has been generally recognized in all parts of the world where amoebic cases are met with, and it is not too much to say that one of the most distressing and intractable diseases of tropical and sub-tropical climates has been conquered.
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In a recent authoritative work on tropical medicine (1) in the section on amoebic abscess of the liver, emetine is said to have " robbed the surgeon of much of the surgery associated with amoebic inflammations of the liver, which, in any degree short of an actual abscess, will almost certainly yield to this treatment. If an abscess appears to be forming, or has already formed, operation is nece...
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ورودعنوان ژورنال:
- Archives of disease in childhood
دوره 41 219 شماره
صفحات -
تاریخ انتشار 1966